Intermediate or brainless phenotypes for psychiatric research?
نویسندگان
چکیده
منابع مشابه
Connectomic Intermediate Phenotypes for Psychiatric Disorders
Psychiatric disorders are phenotypically heterogeneous entities with a complex genetic basis. To mitigate this complexity, many investigators study so-called intermediate phenotypes (IPs) that putatively provide a more direct index of the physiological effects of candidate genetic risk variants than overt psychiatric syndromes. Magnetic resonance imaging (MRI) is a particularly popular techniqu...
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Studies aiming to identify susceptibility genes for schizophrenia and other complex psychiatric disorders are faced with the confounds of subjective clinical criteria, commonly occurring phenocopies, significant between-subject variability of candidate traits, and the likelihood of allelic and locus heterogeneity that has been shown to define the genetics of other complex human brain and somati...
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ژورنال
عنوان ژورنال: Psychological Medicine
سال: 2009
ISSN: 0033-2917,1469-8978
DOI: 10.1017/s0033291709991929